Laura H Jacobson Selected Research

Amyloid Plaque

11/2018	The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
6/2011	The second-generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects.

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Laura H Jacobson Research Topics

Disease

8	Sleep Initiation and Maintenance Disorders (Insomnia) 09/2023 - 01/2013
8	Alzheimer Disease (Alzheimer's Disease) 10/2021 - 06/2011
3	Tauopathies 01/2024 - 01/2021
3	Dementia (Dementias) 09/2023 - 09/2015
3	Narcolepsy 01/2021 - 12/2013
3	Cataplexy 01/2021 - 12/2013
3	Hypothermia 04/2008 - 05/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 12/2013
2	Amyloid Plaque 11/2018 - 06/2011
2	Sleep Wake Disorders 10/2013 - 01/2013
2	Anxiety Disorders (Anxiety Disorder) 01/2010 - 04/2008
2	Ataxia (Dyssynergia) 12/2006 - 05/2005
1	Hallucinations (Hallucination) 01/2023
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2021
1	Asymptomatic Diseases 11/2018
1	Body Weight (Weight, Body) 11/2018
1	Drug Resistant Epilepsy 01/2018
1	Myoclonic Epilepsies (Myoclonic Encephalopathy) 01/2018
1	Seizures (Absence Seizure) 01/2018
1	Anhedonia 01/2018
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2017
1	Substance-Related Disorders (Drug Abuse) 02/2016
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2016
1	Neuroinflammatory Diseases 09/2015
1	Migraine Disorders (Migraine) 12/2013
1	Obesity 12/2013
1	Pain (Aches) 12/2013
1	Weight Loss (Weight Reduction) 12/2011
1	Amyloidosis 08/2009

Drug/Important Bio-Agent (IBA)

8	suvorexantIBA 01/2022 - 01/2013
7	Orexin Receptor AntagonistsIBA 09/2023 - 01/2013
7	Amyloid (Amyloid Fibrils)IBA 11/2018 - 06/2011
6	Orexin ReceptorsIBA 01/2024 - 01/2013
5	Hypnotics and Sedatives (Sedatives)IBA 01/2024 - 01/2017
5	OrexinsIBA 09/2023 - 12/2013
3	almorexantIBA 12/2013 - 01/2013
3	Baclofen FDA LinkGeneric 04/2008 - 05/2005
2	Zolpidem (Ambien)FDA LinkGeneric 01/2022 - 01/2021
2	UmibecestatIBA 10/2021 - 11/2018
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 10/2021 - 02/2016
2	Proteins (Proteins, Gene)FDA Link 11/2018 - 01/2016
2	Peptides (Polypeptides)IBA 01/2018 - 12/2013
2	N- ((1- ((5- (4- fluorophenyl)- 2- methyl- 4- thiazolyl)carbonyl)- 2- piperidinyl)methyl)- 4- benzofurancarboxamideIBA 12/2013 - 01/2013
2	MK-6096IBA 12/2013 - 01/2013
2	GABA-B ReceptorsIBA 04/2008 - 05/2005
2	GABA-B Receptor AgonistsIBA 04/2008 - 12/2006
1	NeuropeptidesIBA 09/2023
1	Hallucinogens (Psychedelics)IBA 01/2023
1	lemborexantIBA 01/2022
1	daridorexantIBA 01/2022
1	BenzodiazepinesIBA 01/2021
1	Antidepressive Agents (Antidepressants)IBA 11/2018
1	Peroxynitrous Acid (Peroxynitrite)IBA 11/2018
1	Fluoxetine (Prozac)FDA LinkGeneric 11/2018
1	VenomsIBA 01/2018
1	Nicotine FDA Link 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	Voltage-Gated Sodium ChannelsIBA 01/2018
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 01/2016
1	NB-360IBA 09/2015
1	EnzymesIBA 01/2012
1	CannabinoidsIBA 12/2011
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 12/2011
1	AntibodiesIBA 06/2011
1	Stainless Steel (Steel, Stainless)IBA 08/2009
1	PrionsIBA 08/2009
1	Anti-Anxiety Agents (Anxiolytics)IBA 04/2008
1	2,6- di- tert- butyl- 4- (3- hydroxy- 2,2- dimethylpropyl)phenolIBA 04/2008
1	N,N'- dicyclopentyl- 2- methylsulfanyl- 5- nitro- pyrimidine- 4,6- diamineIBA 04/2008
1	gamma-Aminobutyric Acid (GABA)IBA 12/2006

Therapy/Procedure

6	Therapeutics 01/2024 - 01/2010
1	Precision Medicine 01/2018
1	Intraventricular Infusions 01/2018
1	Immunotherapy 01/2016
1	Traction 04/2008